P01.30. The role of pH in cancer
نویسنده
چکیده
Purpose Malignant tumors are acidic. The extracellular pH of tumors ranges from 6.5-6.9 versus 7.2-7.4 in normal tissue. Acid-producing tumors are more invasive and exhibit a greater metastatic potential. Tumor acidity is toxic to the surrounding tissue, induces the breakdown of the basement membrane around the tumor, and increases expression and activity of metastatic effectors. Therefore, it is thought that tumor acidity is a selective advantage in promoting cancer progression.
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